Prevagen Side Effects: Is it a Safe Nootropic? (updated)

Disclaimer: Parts of this article were drafted using AI and edited by a human author to ensure accuracy and quality.

Many nootropics on the market today use bogus ingredients when it comes to brain health, some of which are overdosed and potentially unsafe. You’ve probably noticed that many use a proprietary blend, which makes it impossible to see how the ingredients are dosed inside. These are just some of the red flags to look for in an increasing number of risky supplements on the market today.

Is Prevagen one of them? We’re about to find out in this review by analyzing the ingredients inside and checking out what the science says.

About Prevagen

Prevagen is a dietary supplement by the company Quincy Bioscience from Madison, Wisconsin. According to the manufacturer, it is claimed to deliver many benefits such as:

  • Improving memory
  • Clear thinking & sharp mind
  • Increased mental focus
  • Boosting overall brain health and function

Many people today struggle with a lack of concentration or suffer from memory loss, so these claims sound hopeful and promising. But, how will Prevagen work, and will it be safe? Are there any possible adverse reactions that could occur by taking it? Let’s check out the ingredients to get the answer.

Ingredient Formula

As seen from the label, Prevagen comes with 50mcg of Vitamin D, and 20mg of apoaequorin per serving.

Vitamin D is an essential vitamin for our survival. However, it is possible to exceed the necessary daily dose. According to, doses higher than 100mcg per day for a longer period of time are unsafe and can cause excess calcium in the blood.

Another ingredient and the key one in the formula is apoaequorin. It is a protein extracted from the luminescent jellyfish. It is claimed by some studies to work for brain health by improving verbal learning and cognition.

However, these might not be legitimate considering the fact that Prevagen has been charged by the New York State AG and FTC with making false claims regarding the supplement’s brain benefits.

What About The Side Effects?

Now, the main question is, is Prevagen safe? Apoaequorin inside Prevagen is typically used in doses of about 10, 20, and 40mg per day. In this case, there’s 20mg of apoaequorin inside. NCBI states that adverse reactions to taking Prevagen were rare, but happened in some people, such as constipation, headache, nausea, hypertension, and edema.

There were even reports of people with multiple sclerosis that were taking apoaequorin that had depression and suicidal thoughts, although it is not clear if these were connected with apoaequorin consumption.

Most studies say that apoaequorin is considered safe and well-tolerated when taken in doses up to 10mg daily for 90 days. Prevagen uses a much higher dose, so this ingredient could potentially be unsafe for you in the long run. The best idea would be to talk to your doctor if you’re not sure if this is the right product for you.

Keep in mind that apoaequorin is not approved by the FDA and we don’t think it is the safest option for brain health.

We’ve seen many nootropics that use all-natural, approved, and well-dosed ingredients that could support your brain health long-term without having to worry if any adverse reactions would occur.


All in all, is it safe to start taking Prevagen for brain health? In our opinion, if you’re a healthy person, you shouldn’t experience any major adverse reactions, although it is possible if the product is taken consistently for a longer period of time. If you have a condition, it isn’t a smart idea.

Considering many nootropics we’ve seen on the market that have quality and completely safe ingredients in their formula, you can find a much more effective and safer alternative to Prevagen.

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