Is Collagen Better Than Glucosamine for Arthritis?

collagen vs glucosamine for arthritis

In the quest for optimal joint health and the fight against arthritis, many people are exploring the benefits of various dietary supplements. Two commonly discussed supplements are glucosamine and collagen. This article will delve into the details of these two options, examining the benefits and drawbacks of each, and helping you make a more informed decision about which may be best for your arthritis management.


Both glucosamine and collagen show effectiveness in reducing joint pain. With that said, glucosamine may provide quicker relief, while collagen offers more holistic benefits. However, combining them with other supplements like turmeric and Boswellia serrata in a comprehensive joint formula may maximize benefits for joint health.

Understanding Arthritis

Arthritis, characterized by joint pain and stiffness, is a condition that affects millions of people worldwide. [1] The most common types include osteoarthritis and rheumatoid arthritis. Age, genetics, lifestyle, and injuries are all factors that can contribute to the development of arthritis. Traditional treatments often involve medication and physical therapy to help manage symptoms. However, dietary supplements such as glucosamine and collagen have also shown potential in supporting joint health.

What is Collagen?

Collagen is the most abundant protein in the human body, often referred to as the “glue” that holds us together. This essential component plays a critical role in the health of our skin, bones, tendons, ligaments, and most relevantly—our joints. As we age, our body’s natural collagen production declines, potentially leading to joint issues. Many studies suggest that supplementing with collagen, particularly in its easily-absorbed hydrolyzed form, can aid in maintaining joint health, and potentially reduce arthritis symptoms. [2] Typically, it’s taken in grams for maximum effectiveness.

What is Glucosamine?

On the other hand, glucosamine is an amino sugar naturally found in the body and plays a key role in the production of cartilage—the connective tissue that cushions our joints. As we age, glucosamine levels decline, which can lead to joint wear and tear. Some studies suggest that supplementing with glucosamine, particularly in the form of glucosamine sulfate, can help promote the production of cartilage and alleviate joint pain associated with arthritis. [3]

Collagen and Joint Health

Several studies highlight the beneficial effects of collagen on joint health. A literature review confirms that collagen reduced pain in osteoarthritis (OA) patients and other forms of arthritis. This effect is likely due to collagen’s absorption in the intestine and accumulation in the cartilage. Additionally, other studies demonstrated collagen’s beneficial impact on activity-related joint pain, even in young adults without joint disease. But these effects take time, at least several weeks, to fully manifest.

Glucosamine and Joint Health

Research has pointed to glucosamine’s effectiveness in treating joint pain. Glucosamine’s anti-inflammatory and antioxidant properties contribute to its positive effect on joint health, as it activates the body’s natural cell-cleaning process in joints. A systematic review of 18 studies showed that glucosamine sulfate helped with knee osteoarthritis symptoms and pain management.

Glucosamine vs Collagen: Which is Better for Arthritis?

Both glucosamine and collagen have scientific backing for their benefits on joint health. However, their effectiveness can vary based on individual cases. Those seeking faster joint pain relief might benefit more from glucosamine. However, for those looking for more holistic benefits—including skin, hair, nails, eyes, teeth, and gum health—collagen may be a better choice. It’s worth noting that the effectiveness of both supplements could be boosted when taken together, due to their complementary functions in joint health. Consulting with a healthcare provider is recommended before starting any new supplement regimen.


In the battle against arthritis, both collagen and glucosamine emerge as beneficial supplements, each with its unique strengths. Despite the advantages of each, neither should be seen as a singular solution, but rather as part of a comprehensive approach to joint health that includes a healthy diet, regular exercise, and other proven supplements like turmeric, omega-3, and bromelain, to name just a few.


  1. Senthelal S, Li J, Ardeshirzadeh S, et al. Arthritis. [Updated 2022 Jun 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:
  2. Khatri M, Naughton RJ, Clifford T, Harper LD, Corr L. The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. Amino Acids. 2021 Oct;53(10):1493-1506. doi: 10.1007/s00726-021-03072-x. Epub 2021 Sep 7. PMID: 34491424; PMCID: PMC8521576.
  3. Williams C, Ampat G. Glucosamine Sulfate. [Updated 2022 Sep 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:

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